No reason to ever give it up as long as you can still physically do it. If you do it for only the enjoyment of doing it then never give up. We have two bowlers on our senior league that are over 100, they say they are happy to shoot their age every game which they always do.
They just go to keep active but both love bowling. One still throws a 16lb ball and he's 103! He still throws a 200+ now and again. People like that are an inspiration. Seeing that also makes me feel a little better about myself and help me mentally ignore my physical issues. I think to myself "If they can do it then I can do it." Especially being over double my age.
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