There's not a definitive answer for that as it depends on your style, comfort level and what you're trying to achieve. When I was using a wrist device it had several settings and I used to like them all set to the extreme i.e. as much tilt and wrist bend as possible. That's me though and is not true for others. The best thing may be to simply try the various settings and see which gives you the effect and position that you think you're after.
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